PYGO2 and cancer: Additionally, Pygo2 is a novel functional protein, downstream of the Wnt signalling pathway.24 Pygo2 primarily binds to free β‐catenin to promote the progression of cancer by activating β‐catenin target genes, including cyclin D1 and c‐Myc.22, 25 Interestingly, the activation of the Wnt/β‐catenin signalling pathway has been reported to accelerate EMT in bladder cancer cells.26