Fibrosis can be regulated by exercise by improving oxidative properties of skeletal muscle and by inhibiting the actions of NF‐κB, which stimulates an increase in the inflammatory cytokine TNF‐α.41, 69, 70, 71 Inflammation is an indication of muscular remodelling, which exercise can regulate by increasing in I‐kappa‐B‐beta/alpha (IKB‐β/α), which actively inhibits NF‐κB activity.41 This indicates exercise as a logical way to restrict the pathogenic actions of Ang‐II. The gene discussed is NFKB1; the disease is fibrosis.