The hazard ratio for progression or death of G2 patients maintained its statistical significance by multivariate analyses (HR 9.739; 95% CI 2.501–37.929) when adjusted for tumor histology, age, gender, smoking habit, liver metastases, number of organs affected, PD‐L1 tumor expression, NLR, serum LDH, and albumin. This evidence concerns the gene CD274 and neoplasm.