An overexpression of TRF1 and TRF2 has been implicated in various pro‐tumorigenic mechanisms including initiation and progression, migration, metastasis, angiogenesis (El Maï et al, 2014; Picco et al, 2016; Zizza et al, 2019), cancer stemness (Bejarano et al, 2017), telomere maintenance (García‐Beccaria et al, 2015; Bejarano et al, 2017), or immunosurveillance bypass (Biroccio et al, 2013; Cherfils Vicini et al, 2019), making these shelterin subunits interesting multi‐hit targets for cancer treatment. Here, TERF1 is linked to cancer.