In particular, we reported that induction of telomere uncapping by either Trf1 genetic depletion or TRF1 chemical inhibition can effectively block initiation and progression of aggressive tumors in both lung cancer and glioblastoma mouse models, in a manner that is independent of telomere length (Garcia‐Beccaria et al, 2015; Bejarano et al, 2017). The gene discussed is TERF1; the disease is glioblastoma.