In particular, POT1 is mutated in several types of sporadic and familial human tumors, including chronic lymphocytic leukemia (CLL; Ramsay et al, 2013), familial melanoma (Robles‐Espinoza et al, 2014; Shi et al, 2014), Li–Fraumeni‐like families (LFL) with cardiac angiosarcomas (CAS; Calvete et al, 2015), glioma (Bainbridge et al, 2015), mantle cell lymphoma (Zhang et al, 2014), and parathyroid adenoma (Newey et al, 2012). This evidence concerns the gene POT1 and B-cell chronic lymphocytic leukemia.