HCAR2 and inherited lipid metabolism disorder: HCA2 is a Gi‐coupled receptor abundantly expressed in adipocytes and in various immune cells, where it is involved in orchestrating anti‐inflammatory actions.12, 13, 14, 15 Interestingly, in a striking contrast with NA, nicotinamide has only negligible affinity to HCA2, which explains its aforementioned inefficiency in the clinical management of dyslipidaemias.9, 16, 17