Although HCA2 is a Gi‐coupled receptor, it is not unprecedented that its activation is followed by Ca2+‐influx.10, 11 Identification of the so far unknown Ca2+ permeable pore(s) promises to be of great clinical relevance, since it/they could also be targeted in the future anti‐seborrhea/anti‐acne drug development, especially, since unlike eg TRPV3,42 its/their activation results in pure sebostatic effects without triggering up‐regulation and release of pro‐inflammatory cytokines (Figure 6). This evidence concerns the gene HCAR2 and acne.