Among them, the methylation levels of EVI2A, C11orf21, SSX1, bone marrow stromal cell antigen 2 (BST2), and MOB kinase activator 3A (MOB3A) were significantly positively correlated with the OS of patients with ccRCC, while the other four genes (PRR15L, ZNF418, homeobox B6 [HOXB6], RIPK4) were inversely connected with survival. The gene discussed is HOXB6; the disease is nonpapillary renal cell carcinoma.