Finally, it was found that the related sites of EVI2A (cg23352695), PRR15L (cg03496533, cg18052778, cg15738800), RIPK4 (cg05306310), SSX1 (cg17158811) and ZNF418 (cg15060012, cg11998703, cg21444693, cg26356061, cg18673377) driving genes were negatively correlated with their expression levels, which may result from the downregulation of ccRCC gene expression that caused by hypermethylation. The gene discussed is RIPK4; the disease is nonpapillary renal cell carcinoma.