Moreover, van Vlodrop et al. (2017) demonstrate that the four gene promoters composed of Gremlin 1, DAN Family BMP Antagonist, neuralized E3 ubiquitin protein ligase 1, Ladinin 1, and neurofilament heavy can be used as prognostic markers of ccRCC. The gene discussed is NEFH; the disease is nonpapillary renal cell carcinoma.