Afterwards, we explored the connection of driving gene methylation, gene expression and the prognosis of patients via survival analysis and joint survival analysis on the basis of available data, and identified the methylation‐driven genes, EVI2A, C11orf21, SSX1, PRR15L, ZNF418, and RIPK4, which can be used as prognostic markers of ccRCC. The gene discussed is C11orf21; the disease is nonpapillary renal cell carcinoma.