Finally, it was found that the related sites of EVI2A (cg23352695), PRR15L (cg03496533, cg18052778, cg15738800), RIPK4 (cg05306310), SSX1 (cg17158811) and ZNF418 (cg15060012, cg11998703, cg21444693, cg26356061, cg18673377) driving genes were negatively correlated with their expression levels, which may result from the downregulation of ccRCC gene expression that caused by hypermethylation. Here, SSX1 is linked to nonpapillary renal cell carcinoma.