Conversely, we observed that HSPB8 mRNA levels showed inverse correlation with HOXB13 and AR mRNA expression  in multiple gene expression data sets including Moffitt TCC data set, GSE21034, GSE101607, GSE6752, GSE67980 and SU2C/PCF datasets (Fig. 7a–i; Supplementary Fig. 9). Here, AR is linked to tarsal-carpal coalition syndrome.