We observed that expression of a majority of the HOTPAM9 kinase expression was significantly impacted when HOXB13 expression was silenced with HOXB13 siRNAs in C4-2B and LNCaP and in VCaP cells to a certain extent (BUB1, NEK2, and AURKA) growing in charcoal stripped media, but not in the small cell carcinoma cell line PC3 (Fig. 2e,f, Supplementary Fig. 2e). This evidence concerns the gene BUB1 and small cell carcinoma.