We observed that following HOXB13 reduction, genes which are highly expressed in C4-2B/pHOXB13KO were downregulated in human prostate tumors while those with reduced expression in C4-2B/pHOXB13KO were upregulated in human prostate tumors compared to normal prostates (Fig. 1b). The gene discussed is HOXB13; the disease is prostate neoplasm.