HSPB8 and tarsal-carpal coalition syndrome: Conversely, we observed that HSPB8 mRNA levels showed inverse correlation with HOXB13 and AR mRNA expression  in multiple gene expression data sets including Moffitt TCC data set, GSE21034, GSE101607, GSE6752, GSE67980 and SU2C/PCF datasets (Fig. 7a–i; Supplementary Fig. 9).