SMARCB1 and medulloblastoma: RTPS1 patients carry germline heterozygous truncating loss-of-function mutations or large deletions, and somatic loss of heterozygosity leads to malignant intracranial and extracranial rhabdoid tumors as well as other malignancies such as CP carcinomas, medulloblastomas, and central primitive neuroectodermal tumors45.