Here, we hypothesize that TGF-β is a major altered signaling pathway after IFITM3 silencing: IFITM3 knockdown may participate in tumor cell adhesion and division by affecting TGF-β signaling and regulating P53 and MAPK signaling through TGF-β inactivation, which affected the malignant proliferation and metastasis of PCa cells. This evidence concerns the gene TGFB1 and neoplasm.