IFITM3 and posterior cortical atrophy: By examining the key molecules of common pathways such as cell cycle, proliferation using the Western blotting method, we found that P38-MAPK activation was significantly weakened and the expression level of cell cycle-related proteins CDK1 and CDC2 was decreased, suggesting that IFITM3 may affect the proliferation of PCa cells through regulating cell cycle mediated by MAPK pathway.