ASNS and major depressive disorder: The strongest association signals for baseline GR/HGA were within a locus on chromosome 7 containing two central genes: TAC1 (protachykinin-1) that has been linked to depression and anxiety85 and ASNS (asparagine synthetase [glutamine-hydrolyzing]) that is an important enzyme, the deficiency of which leads to substantial neurodevelopmental deficits86.