No comparable effect on IE gene expression was evident in primary infection of MoDCs or fibroblasts (Fig. S2), nor was IL-6–induced expression of c-fos mRNA affected in reactivating MoDCs (Fig. 2b), suggesting that pan-inhibition of IL-6–responsive genes was not occurring and, furthermore, that the requirement for SFK activity to drive viral IE gene expression was restricted to latency and reactivation. This evidence concerns the gene FOS and infection.