The absence of associations between tau in the hippocampus and atrophy could be due to our relatively young sample (mean age 65 ± 8 years) and the inclusion of subjects with non-amnestic presentations, which are associated with an atrophy pattern more pronounced in cortical regions and relative sparing of hippocampus and other medial temporal structures [44–46]. The gene discussed is MAPT; the disease is Atrophy.