TNF and neoplasm: NF-κB is a key factor in inflammatory response, which can not only enter cell nucleuses, accelerating the further expression of inflammatory factors, such as IL1B, TNFA and PTGS2, but also block apoptosis by activating inhibitor of apoptosis proteins BCL-2 and BCL-XL, and participate in angiogenesis and tumor spreading by regulating VEGF and IL-8 [53].