Until a reevaluation is available and possible, the therapy with dual-release cortisone, resulting in lower ACTH (and most probably lower α-MSH levels as its cleavage product, although not measured in this study) might be a wiser therapeutic approach in terms of hydrocortisone replacement therapy in MM patients with ICI-therapy induced primary adrenal failure. This evidence concerns the gene POMC and Miyoshi myopathy.