NFKB1 and familial pancreatic carcinoma: O-GlcNAcylation of NF-κB on Thr352 and Th322 in pancreatic cancer cells [37] stabilizes and increases its activity, as it prevents the binding of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IκBα), an inhibitor of NF-κB, thus allowing NF-κB to enter the nucleus and block apoptosis (Fig. 4).