The local fumarate produced from promoter-associated FH blocks lysine-specific demethylase 2A (KDM2A) activity, resulting in histone H3 lysine 36 methylation (H3K36me2) stabilization and transcription of activating transcription factor 2 (ATF2)-targeted genes responsible for cell growth arrest in cancer cells [72]. The gene discussed is FH; the disease is cancer.