TNF and chronic myelogenous leukemia, BCR-ABL1 positive: Aiming to analyze if TNFα upregulation was specific for the stem and progenitor cell compartment or not, we next tested whole BM cells from control and SCLtTA/Bcr-Abl CML mice in that we induced the disease for 6 days by tetracycline withdrawal which lead to the activation of the oncogenic Bcr-Abl kinase.