Univariable analysis of the Cox proportional hazards regression model identified the following variables for multivariable analysis: sex, age, history of hypertension, UPE, estimated glomerular filtration rate (eGFR), serum uric acid, IgA, C3, C4, treatment with RASIs, mesangial hypercellularity, segmental sclerosis, tubular atrophy/interstitial fibrosis, crescents and ratios of global sclerosis (Table 1). The gene discussed is C3; the disease is Hypertension.