As is known, many cytokines are involved in the pathogenesis of autoimmune diseases.S100B is a member of the S100 family and primarily secreted by astrocytes, but to alesser extent it is also produced by other cell types, such as dendritic cell,macrophages, monocytes, and T cells (Donato,et al., 2009, 2013; Miki, et al.,2013). This evidence concerns the gene S100B and autoimmune disease.