APOE and Alzheimer disease: The first primary objective of the study is to investigate correlations between CSF biomarkers of synaptic injury (Ng and SNAP-25) and FC in the DMN using resting state fMRI (adjusting for age, gender, and the apolipoprotein E4 [APOE4] genotype) in AD (CDR 0.5-1) and controls (CDR 0).