Bone marrow‐derived mononuclear cells that were tested positive for high HMGA2 expression (Marquis et al., 2018) comprise of a myriad of cells at different stages of maturation, with hematopoietic stem (HPS) cells playing a central role in the development of AML (Corces et al., 2017; Cuende et al., 2012; Sanchez‐Aguilera and Mendez‐Ferrer, 2017). The gene discussed is HMGA2; the disease is acute myeloid leukemia.