TP53 and neoplasm: In addition, several tumor‐associated proteins such as YB‐1 (Wu et al., 2014), p53 (Gobert et al., 1996) (Kwon et al., 2000) and ARF (Karayan et al., 2001) have been shown to enhance TOP activity either through direct protein–protein interactions or by enhancing TOP2 ATPase activity.