Although the mean LVEF differed little according to diabetes status or the use of insulin, patients treated with insulin had worse NYHA functional status, more HF‐related signs and symptoms, and worse health‐related quality of life, as indicated by a substantially higher MLWHF score and lower KCCQ clinical summary score compared to patients with diabetes not on insulin and, in particular, those without diabetes. The gene discussed is INS; the disease is diabetes mellitus.