Such conditions may include aging and age‐related neurodegenerative diseases, such as polyglutamine diseases, where aggregated proteins colocalize with PML‐NBs and deplete nuclear ubiquitin (Ben Yehuda et al, 2017), and ALS, which is linked to mutations in genes involved in PQC and DNA repair (Gao et al, 2017; Walker et al, 2017; Chia et al, 2018). The gene discussed is PML; the disease is amyotrophic lateral sclerosis.