CRHR1 and Anxiety: Activation of CRHR1 in several limbic brain areas, including CeM, BNST, or PAG, results in increased anxiety and preferentially sustained fear reactions.81 These structures also receive projections from arcuate AgRP/NPY neurons, suggesting a possible interaction node with food intake.29, 82 While retention of conditioned fear may be enhanced by CeA–CRH neurons,83 the overall role of CRH in the CeA is still controversial.