CRHR1 and Anxiety: Several studies95, 96, 97, 98 illustrate that ghrelin induces anxiety‐like behaviors, while injection of a CRHR antagonist blocked this effect, suggesting an interaction of CRH and ghrelin.98 CRH‐releasing neurons in the PVH initiate the activation of the HPA axis responsible for stress adaptation by corticosterone release (Fig. 4).