In addition, peripheral injected CCK potentiated anxiety‐induced 5‐HT release in the mPFC in guinea pigs.145 This is an interesting finding, since both CCK and 5‐HT are known to reduce food intake and promote anxiety‐related behaviors.130 It also demonstrates that peripherally released CCK does not only modulate food‐intake, but also emotional‐affective behaviors. Here, CCK is linked to Anxiety.