NPY and Anxiety: Excellent reviews on the role of CCK in fear on anxiety have been published elsewhere.130, 131 In brief, CCK agonists increased anxiety‐like behavior in several behavioral paradigms.132 These effects were attenuated by ICV injections of NPY and potentiated by the Y1R antagonist BIBP3226,133 suggesting an interaction of anorexigenic CCK and orexigenic NPY also in emotional‐affective processing.