Activation of CRHR1 in several limbic brain areas, including CeM, BNST, or PAG, results in increased anxiety and preferentially sustained fear reactions.81 These structures also receive projections from arcuate AgRP/NPY neurons, suggesting a possible interaction node with food intake.29, 82 While retention of conditioned fear may be enhanced by CeA–CRH neurons,83 the overall role of CRH in the CeA is still controversial. The gene discussed is NPY; the disease is Anxiety.