CRH and Anxiety: Along these lines, central or intranasal applications of MC4R antagonists have shown promising results in reducing various behavioral symptoms associated with post‐traumatic stress disorder.73, 74, 157 In addition to neuropeptides, GABA released from AgRP/NPY neurons may mediate tonic inhibition of anxiogenic CRH release in the CeL.158 Indeed, in high anxiety–related behavior mice, α5 and γ1 subunits of the GABAA receptor were specifically downregulated, a phenomenon that may reduce tonic inhibition and increase anxiety.159