CYTOR and malignant colon neoplasm: Additionally, transfecting colon cancer cells with the linc00152 gene decreases cellular activity, but enhances apoptosis.37 In‐depth research revealed that the hypoxic microenvironment of cancer tissues can increase the abundance of miR‐376c‐3p, which can negatively regulate linc00152 expression, and affect its target genes (eg, ki‐67, Bcl‐2, and Fas) to activate apoptosis pathways.