The signaling pathway comprising type IA PI3K and its downstream molecular protein kinase B (PKB or AKT) was recently determined to be closely related to the development and progression of human tumors.32 This pathway regulates the proliferation and survival of tumor cells, and its abnormal activity can lead to the development of malignant cells, while also facilitating cellular migration, adhesion, tumor angiogenesis, and the degradation of the extracellular matrix (Figure 3). Here, AKT1 is linked to neoplasm.