The poor prognosis and very short overall survival of many intractable cancers are strictly related to linc0052 overexpression, including esophageal squamous cell carcinoma,60 lung cancer,45, 56 and hepatitis B virus‐associated HCC.49 Another study demonstrated that poor prognosis and chemoresistance in several cancers can be induced by the binding between EZH2 and increasing amounts of linc00152.62 This evidence concerns the gene EZH2 and cancer.