AKT1 and obesity due to melanocortin 4 receptor deficiency: SFN and 5‐fluorouracil have been shown to synergistically reduce cell growth in a triple‐negative breast cancer line by inducing autophagic cell death and premature senescence.87 In addition, epidermal squamous cell carcinoma and malignant mesothelioma can be treated using a combination of SFN and cisplatin, which inhibits tumour cell proliferation and accelerates tumour cell autophagy.88, 89 Furthermore, the combination of SFN and myricetin can induce fat cell apoptosis through Akt‐mediated mitochondrial apoptosis,90 which may also represent a novel strategy for the treatment of obesity.