KEAP1 and familial dilated cardiomyopathy: Nrf2 is located in the cytoskeleton, bound to Kelch‐like ECH‐associated protein 1 (Keap1).23 Oxidative stress causes Nrf2 to dissociate from Keap1 and to subsequently translocate into the nucleus, which results in its binding to AREs and the transcription of downstream target genes, including genes that encode antioxidants, detoxifying enzymes, antiapoptotic proteins and proteasomes,24, 25, 26 stress and prevent DCM.27, 28, 29, 30, 31