MCAT and familial dilated cardiomyopathy: Previous studies have clearly shown that both Nrf2 and MT play important roles in the prevention of DCM.26, 29, 46 For the induction of Nrf2, most studies used SFN,58, 76, 77 whereas studies on the induction of MT used Zn.78, 79, 80 To date, no studies have evaluated the combination of SFN and Zn for the treatment of DCM.