In addition, the serum IL‐6 and TNF‐α levels of the FAIM‐overexpression group (LV‐FAIM) and PACAP‐injected groups (PACAP) were lower than those of the obesity group (Obesity), but the serum IL‐6 and TNF‐α levels of the FAIM knockdown group (LV‐shFAIM) were also increased compared with those of the obesity group (Obesity) (Figure 5A). Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.