Obesity is often associated with insulin resistance and chronic systemic inflammation, the blood inflammatory markers, including monocyte chemoattractant protein‐1 (MCP‐1), RANTES, IL‐6, and TNF‐α were evaluated in obese human than normal controls.22, 23 To explore the effects of FAIM on the inflammatory and insulin sensitivity, we overexpressed FAIM in obese mice with lentivirus, found that the levels of inflammatory factors, blood glucose, serum triglycerides and total cholesterol decreased. Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.