In addition, the serum IL‐6 and TNF‐α levels of the FAIM‐overexpression group (LV‐FAIM) and PACAP‐injected groups (PACAP) were lower than those of the obesity group (Obesity), but the serum IL‐6 and TNF‐α levels of the FAIM knockdown group (LV‐shFAIM) were also increased compared with those of the obesity group (Obesity) (Figure 5A). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.