TNF and Sepsis: One study reported patients with the TNF-α-308 GG genotype had fourfold higher odds of a post-operative infection: OR 4.2 (CI 1.7–10.5),39 whilst another reported that it was the AA genotype which was associated with infection with OR 4.17 (CI 1.5–11.48).40 We can compare this with the results of a previous meta-analysis which examined TNF-α-308 in sepsis more generally.