Growth factors and cytokines within the secretome such as transforming growth factor beta isoform 3 (TGF-β3) [17], hepatocyte growth factor (HGF), IL-10, and tumor necrosis factor-alpha (TNF-α) [18] can modulate cell signaling and processes involved in fibrogenesis and can attenuate liver fibrosis. The gene discussed is TNF; the disease is Hepatic fibrosis.