For this analysis, we added additional markers previously suggested to be differentially expressed by Tph cells (TIGIT, ICOS, HLA-DR, CCR2 and CD27) [12] to determine whether a certain combination of these phenotypic markers would better define the CXCR5−PD-1hi cell population expanded in children with type 1 diabetes. The gene discussed is TIGIT; the disease is type 1 diabetes mellitus.