Surprisingly, stromal keratitis manifested an earlier onset and was more severe in NLRP3 KO mice than WT mice, along with significantly increased early neutrophil infiltration and corneal neovascularization, while suppression of early neutrophil infiltration prevented the early onset of keratitis and reduced the level of cleaved IL-1β in NLRP3 KO mice27. The gene discussed is IL1B; the disease is keratitis.