The result observed in mesothelioma cell lines (Fig. 4a) showed that antibody-mediated inhibition is able to decrease tyrosine phosphorylation on EphB4 immunoprecipitates at inhibition levels higher than those exerted on the whole protein (compare Fig. 2b with Fig. 4a) suggesting that autocrine IGF-II could affect EphB4 tyrosine phosphorylation independently or preceding the reduction on steady-state protein expression. Here, EPHB4 is linked to mesothelioma.