Based on our previous findings demonstrating the cardioprotective efficacy of the Gal-3 inhibitor MCP in a variety of cardiovascular pathologies5,6,8,9, we tested the hypothesis that MCP treatment provides cardioprotection against LV remodeling associated to IR injury in rats, delaying the adverse remodeling that leads to progressive LV dysfunction and HF. The gene discussed is LGALS3; the disease is hydrops fetalis.