Additionally, serotonin-dependent activation of the serotonin receptor (5-HTR2A) inhibits HDAC2 promoter activity in human cells64, while 5-HTR2A inhibition increases Hdac2 transcription and negatively affects synaptic remodeling and cognitive behavior through NF-κB signaling in rodents65, which may have relevance to depression and other neuropsychiatric disorders. This evidence concerns the gene NFKB1 and major depressive disorder.