NEO1 and cancer: Further, the nine genes (LSM4, BUR6, ERG7, KRS1, SPC3, GPN2, TSC13, MUD1, and NEO1) with known human homologs not already associated with cancer phenotypes are prime candidates as novel cancer susceptibility genes as they, like their yeast counterparts, may be able to induce haploinsufficient effects, not abiding the two-hit hypothesis, and therefore being more impactful gene mutations.