In an ovalbumin murine asthma model, exposure to PM2.5 exacerbated the asthma symptoms by significantly increasing the expression of RORα and GATA3 levels in peripheral blood mononuclear cell, transcription factors related to ILC2, suggesting that ILC2s play a crucial role in serious asthma induced by PM2.5 [56]. The gene discussed is RORA; the disease is asthma.