IGHE and rhinitis: As IL-5 and IL-13 are also produced by Th2 cells and are responsible for IgE class switching on B cells and the recruitment and activation of eosinophils [66,67,68,69], ILC2s stimulated by air pollutants likely act synergistically with Th2 cells to mount allergic respiratory processes, such as rhinitis and asthmatic episodes associated to air pollutants.