Because 90% of HCC cases have a natural history of unresolved inflammation and severe fibrosis (or cirrhosis), we then examined the fibrosis marker genes, including collagen type I alpha 1 (cola1a1), connective tissue growth factor (ctgfa), and heparanase (hpse) in the AURKA transgenic fish. The gene discussed is CCN2; the disease is hepatocellular carcinoma.