AKT1 and cancer: The novel non-canonical role of AURKA in DNA replication has been revealed [29], promoting tumor progression, including inducing phosphorylation of Akt and mammalian target of the rapamycin (mTOR), phosphorylation of mitogen-activated protein kinase (MAPK), and activation of epithelial–mesenchymal transition (EMT) reprogramming, making AURKA an attractive target for cancer therapeutics [28].