CYP3A4 and type 2 diabetes mellitus: No significant difference was measured for the formation rate of the various metabolites (mean ± SD) between individuals without T2D or patients with T2D for CYP2C9 (0.41 ± 0.12 vs. 0.48 ± 0.26 pmoles mg protein−1 min−1), CYP2J2 (1.69 ± 0.93 vs. 2.16 ± 1.70 pmoles mg protein−1 min−1) or CYP3A (5.02 ± 4.76 vs. 5.25 ± 3.72 pmoles mg protein−1 min−1) (p-value > 0.05, Figure 2).