Histological examinations in TUBA1A mutated brains revealed structural abnormalities of the cortex, a fractured pyramidal layer of the hippocampus, and defects attributed to impairment of neuronal migration mechanisms, similar to the mouse models of lissencephaly (LIS1, DCX, RELN) [51,52,53,54]. This evidence concerns the gene TUBA1A and Lissencephaly.