Pharmacological AMPK activation with AMPK activators such 5-amino-1-β-d-ribofuranosyl-imidazole-4-carboxamide (AICAR), metformin, or resveratrol as well as exercise-induced AMPK activation leads to a reduction of inflammatory nociception, neuropathic pain, and cancer pain, respectively [14,15,16,17]. Here, PRKAA2 is linked to cancer.