Nonetheless, according to Beverly et al. (2013) and Merino et al. (2012), cancer cells evade apoptosis by relying on up-regulation of Bcl-2 like proteins for survival, therefore it is a good that ZnPcSmix mediated PDT has an ability to down-regulate BCL2L2 and BCL2L10 [36,39]. The gene discussed is BCL2L2; the disease is cancer.