CTNNB1 and neoplasm: Furthermore, when intravenous delivery of CTNNA1 and CTNNB1 siRNAs loaded with CA nanoparticles was done in the 4T1 tumor bearing the Balb/c mice model, the reduced tumor volume compared to the CA nanoparticle treated controls (Figure 11a and Figure 12a) indicated the role of these genes in tumorigenesis.