P2X3 is highly expressed in small- and medium-sized nociceptors of dorsal root ganglions (DRGs) and has been associated with pain response in multiple animal pain models, including the bone cancer pain model, chronic constriction nerve injury (CCI) model, spared nerve injury (SNI) model, and the CFA model [10,11,12,13]. The gene discussed is P2RX3; the disease is bone cancer.