Among them, LMP1 and EBNA2 have been extensively studied.14, 15 In particular, it is well established that EBNA2 is crucial for the viral transformation of B‐lymphocytes.16 Although there are observations indicating that the presence of EBV is correlated with higher expression of PD‐L1 in DLBCL and BL, there are, to our knowledge, no comprehensive reports on its expression in pediatric and adolescent patients with PTLD, particularly, not on the entire spectrum of PTLD categories, including early, non‐destructive lesions. This evidence concerns the gene CD274 and diffuse large B-cell lymphoma.