With respect to the serum lipid indexes, the ApoE-/- mice in the HFD group developed remarkable features of hyperlipidemia, with a significant increase in the TG concentration (p < 0.05), TC concentration (p < 0.001), and atherosclerosis index (p < 0.001; Fig 1E–1H). The gene discussed is APOE; the disease is atherosclerosis.