Among the genes identified to have splice sites associated with GWAS SNPs were CDK11A, which may be of biological relevance for COPD due to its role in apoptosis; SULT1A2 which has both eQTLs and sQTLs which strongly colocalize to the GWAS signal; and of particular interest, FBXO38, in which a novel exon may be protective against COPD. The gene discussed is FBXO38; the disease is chronic obstructive pulmonary disease.