HEPHL1 and neoplasm: Investigation of EBV miRNA target genes revealed the inhibition of tumor suppressor genes and upregulation of multiple EBV‐encoded miRNAs in NPC.44 The BART miRNA cluster was related to the expression of LMP1, Zp, gp350, and EBNA1.45 Chan et al demonstrated that tissue EBV microRNA BART7 is useful for identifying a subgroup of patients with histologically clear margins who were at increased risk of subsequent local tumor recurrence.46 Considering the finding that patients with lrNPC and high EBV DNA levels were at greater risk of second local recurrence.