HOP92shcontrol cells were injected into the left lung of mice but resulted in limited formation of primary tumours at day 30 (1/7 mice, 16%), which was increased upon silencing of RASSF1A (3/7 mice, 42%) with evidence of at least one metastatic event (Fig EV1E, Table EV2). The gene discussed is RASSF1; the disease is neoplasm.