NLRP3 and infection: As GBPs are known to be involved in pyroptosis, and Tg infection of rodent macrophages causes pyroptosis via NLRP1 and NLRP3 (Cirelli et al, 2014; Ewald et al, 2014; Gorfu et al, 2014), we reasoned that human macrophages infected with Tg might also undergo pyroptosis.