Because CB1R binding inhibits calcium entry into the presynaptic neuron via N-, P-, and Q-type calcium channels,58,59 the presence of fewer CB1Rs may dysregulate calcium and potassium channels, leading to neurochemical alterations in psychosis.34,35,36,60,61 Because CB1Rs modulate neurotransmitters implicated in psychosis, including dopamine,62 glutamate,63 and γ-aminobutyric acid,58 future studies are needed to investigate whether CB1R alterations precipitate other neurochemical alterations in psychosis. The gene discussed is CNR1; the disease is psychotic disorder.