Although the Wechsler Digit Symbol Coding Test is highly correlated with global cognitive impairments,31 this measure lacks specificity at the expense of sensitivity, and which precise aspect of cognition is affected is unclear.69 This measure was chosen to minimize participant burden but, given our findings, determining whether CB1R availability is associated with specific aspects of cognition would be useful. The gene discussed is CNR1; the disease is Cognitive impairment.